Vitamin D3, also known as cholecalciferol, is extremely important for the body. Getting the required daily amount of this vitamin signiicantly reduces the risk of experiencing serious health problems. The human body’s main source of vitamin D3 is exposure to sunlight; a thermal process which takes place in the skin transforms a certain form of cholesterol into vitamin D3. The vitamin D3 produced in the skin then passes into the bloodstream and through the liverand kidneys, becoming transformed into its biologically active form. Clinical studies show that low levels of 25(OH)D (the main active form of vitamin D3) arecorrelated with late ARMD, suggesting that vitamin D3 may play a protective role in the progression of the disease. This beneit may be explained by the presence of speciic receptors for vitamin D in the retina, and by its anti-inlammatory and anti-angiogenic activity, which is already well documented. Therefore, vitamin D3 may have a part to play in preventing the onset and progression of ARMD by acting to control the inlammation and the processes which alter the structure of the retinal tissue. Vitamin C, or ascorbic acid, belongs to the water-soluble vitamin group: vitamins which cannot be stored in the body, but must be ingested regularly as part of the diet. Vitamin C is a powerful antioxidant which, thanks to its chemical and physical properties, is capable of neutralising all reactive oxygen species. Vitamin E, or tocopherol, is a fat-soluble vitamin which protects the cell membranes from oxidation and removes free radicals. It is stored in the liver, and therefore does not need to be ingested regularly in food. Rather, the body releases it in small doses as it is needed. The critical role that it plays in controlling damage from oxidative stress is highlighted by the serious harm caused by vitamin E deiciency (peripheral neuropathy, cerebellar ataxia, retinopathy, etc.).